Promising results from CBD on Alcohol Use Disorder
Frontiers in Pharmacology cites a 2017 Clinical Trial asserting Promising results from CBD on Alcohol Use Disorder (AUD). Concluding that CBD could directly reduce alcohol drinking in subjects with AUD. While any other applications warrant human trials in this population.
Study Background
The study focused on three (3) AUD related symptoms. CBD for reducing alcohol drinking. CBD for reducing alcohol-related liver inflammation. And cannabidiol for reducing alcohol-related brain injuries.
Experimental data suggest that CBD could be used for various purposes in alcohol use disorder (AUD) and alcohol-related damage on the brain and the liver. Citing CBD’s complex immunomodulatory, antioxidant, anxiolytic, and antiepileptic properties as its foundation.
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Chronic alcohol consumption is a leading cause of alcoholic liver disease in the USA and worldwide, which eventually may progress to cirrhosis or hepatocellular carcinoma in susceptible subjects. Interestingly, while most heavy drinkers develop fatty liver, only about 20% of them will develop liver cirrhosis.
Effects of CBD from Binge Alcohol feeding
The study investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice. In short, the analysis demonstrated that CBD lessened elevated liver enzymes and increased liver triglyceride. It also reduced fat droplet accumulation.
Key Results
Also of note, CBD improved the alcohol-induced liver metabolic impairment and abnormal retention of lipids. Essentially, CBD may be a potential therapeutic treatment for alcoholic liver diseases “associated with inflammation, oxidative stress, and steatosis.”
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Experimental studies found that CBD reduces the overall level of alcohol drinking in animal models of AUD. Key results suggest CBD reduces ethanol intake, motivation for ethanol, relapse, anxiety, and impulsivity. Finally, CBD reduces alcohol-related brain damage. Hence, preventing neuronal loss by its antioxidant and immunomodulatory properties.
Conclusions | Promising results from CBD on Alcohol Use Disorder
CBD could directly reduce alcohol drinking in subjects with AUD. Any other applications warrant human trials in this population. By reducing alcohol-related steatosis processes in the liver, and alcohol-related brain damage, CBD could improve both hepatic and neurocognitive outcomes in subjects with AUD, regardless of the individual’s drinking trajectory.
You can read the full Clinical Study here
